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Fetale Programmierung

AG Prof. Dr. med. Silvia Lobmaier

Unsere Forschungsschwerpunkte sind:
  • Fetale Programmierung
  • Fetale Wachstumsrestriktion
  • Pränataler Stress
  • Fetales autonomes Nervensystem
  • Optimierung der CTG Überwachung (signal processing)
  • Fetale funktionelle Echokardiographie


Wissenschaftliches Netzwerk:


Mitglieder und Kooperationspartner der Arbeitsgruppe Lobmaier „fetale Programmierung“:

Name


Dienststellung (Funktion), Klinik

Prof. Dr. S. Lobmaier

Gynäkologie, Klinikum rechts der Isar der Technischen Universität München


Prof. Dr. M. Antonelli

Biochemistry/Neurochemistry University Buenos Aires, Argentina

Visiting Professor TUM 2016, 2017, 2018, 2019, 2020, 2021, 2021, 2022.

Prof. Dr. M. G. Frasch

Dept. of Obstetrics and Gynecology, University of Washington, Seattle, USA (Dr. M. Frasch)

Visiting Professor TUM 2022

Prof. Dr. A. Etemad

Department of Electrical and Computer Engineering, Queen’s University, Canada

Dr. Hau-Tieng Wu

Department of Mathematics and Department of Statistical Science at Duke University

Dr. M. Waldenberger

Helmholtz Zentrum München; Deutsches Forschungszentrum für Gesundheit und Umwelt

Prof. Dr. R. Ensenauer

LMU München, Arbeitsgruppe Molekulare Ernährung; Universität Düsseldorf, Professorin Stoffwechsel- & Ernährungsforschung; Leiterin Institut für Kinderernährung, Max Rubner-Institut Karlsruhe

Prof. Dr. C. Prazeres da Costa

Abteilung diagnostische Parasitologie und Co-Leiterin der Lehreinheit am Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Technischen Universität München; Mitbegründerin des Center for Global Health der TUM

Prof. Dr. R. Oberhoffer-Fritz

Lehrstuhlinhaberin Präventive Pädiatrie. Kinderkardiologie Deutsches Herzzentrum München

PD Dr. A. Wacker-Gussmann

Präventive Pädiatrie. Kinderkardiologie Deutsches Herzzentrum München

PD Dr. J.U. Ortiz

Gynäkologie, Klinikum rechts der Isar der Technischen Universität München

Prof. Dr. B. Kuschel

Gynäkologie, Klinikum rechts der Isar der Technischen Universität München

Dr. E. Ostermayer

Gynäkologie, Klinikum rechts der Isar der Technischen Universität München

PD Dr. O. Graupner

Klinik für Gynäkologie und Geburtsmedizin, Uniklinik RWTH Aachen



Dr. R. Sharma (PhD)

PhD Studentin

S. Molinet

Doktorandin

M. Meyer

Doktorandin

C. Becker

Doktorandin

A. Leeb

Doktorandin

L. Gasser

Doktorandin

M. Falcao

Doktorandin

N. Wildner

Doktorandin

C. Ried

Doktorandin

Dr. P. Zimmermann

Ehemaliger Doktorand

Dr. C. Zelgert

Ehemalige Doktorandin

Dr. E. Ludwig

Ehemalige Doktorandin

Dr. C. Plankl

Ehemalige Doktorandin

Dr. J. Harder

Ehemalige Doktorandin

M. Sewald

Doktorandin

C. Hillerup

Doktorandin

Dr. T. Hammerl

Ehemaliger Doktorand

Dr. A. Setter

Ehemalige Doktorandin



Derzeit laufende/kürzlich abgeschlossene Projekte:

  • CURIOSA Studie: Fetal programming: Evaluation of CardiovascUlar Remodeling In late-Onset Small-for-gestational-Age fetuses and prediction of adverse birth and long-term cardiovascular outcome: EKFS Antrag Dr. S.M. Lobmaier (in Kooperation mit DHZ- Prof. Dr. Oberhoffer/PD Dr. A. Wacker-Gußmann, I. Med- Prof. G. Schmid/A. Müller, Plazentapathologie Universität Jena/Oslo, Abteilung für Stoffwechsel und Ernährung- Prof. Dr. Ensenauer).       

      Details zur Curiosa-Studie:

Gefördert durch

(link is external)

  • FELICITy Studie: Fetal EarLy non-Invasive biomarkers of chronic maternal stress during pregnancy resulting in alterations of infant CognItive developmenT: translating fetal programming due to stress into bedside diagnostic and prognostic tools. Prof. Dr. S.M. Lobmaier/Prof. Dr. M. Antonelli (university Buenos Aires) in Kooperation mit dem Helmholtz Zentrum München (Dr. Waldenberger)
  • FELICITy 2 Studie: AnkerFELICITy2 - Non-pharmacological interventions in stressed pregnant women 

          Details zur Felicity2-Studie

  • TRUFFLE-2: zerebraler Doppler bei später Wachstumsrestriktion: Prof. Lees (Imperial College London, Head of Fetal Medicine & Honorary Consultant in Obstetrics, Centre for Fetal Care, Queen Charlotte’s & Chelsea Hospital, London)
  • Immunologie/Global health: Analyse der Expression von Kandidatengenen in Plazenta und des peripheren Zytokinprofils sowie des Vitamin D Status zum Zeitpunkt der Geburt (Kooperation mit Prof. C. Prazeres da Costa Parasitologie/Immunologie TUM -> Center for Global health).

          Details zur TRUFFLE-2-Studie:


Abgeschlossene Projekte:

  • PRSA zur Prädiktion des schlechten Outcomes bei Frühgeborenen: Prof. Wolf/W. Ganzevoort (ACM Amsterdam university)
  • Prävention/Kardiologie (“GEDIVA Studie”): Gestationsdiabetes: Bewegung in der Schwangerschaft und deren Einfluss auf das mütterliche und kindliche kardiovaskuläre System sowie Veränderungen der fetal cardiac function: Prof. Oberhoffer/Wacker-Gussmann sowie metabolische Veränderungen: Prof. Ensenauer
  • SUGAr Studie: StUdie GestAtionsdiabetes: Welchen Einfluß hat körperliche Bewegung während der Schwangerschaft auf die Herz-Kreislauf-Funktion von Mutter und Kind? PD Dr. A. Wacker-Gussmann/ Prof. Dr. S.M. Lobmaier/Prof. Dr. Oberhoffer
  • FEMALE Studie: FEtal and MAternaL Electrocardiography: Doktorandin C. Plankl, Dr. A. Wacker-Gußmann (DHZ München), Prof. Dr. KTM Schneider, Dr. S.M. Lobmaier: (Frauenklinik rechts der Isar). Fetales EKG in der Schwangerschaft: Kohortenstudie.

1. Phasengleichgerichtete Signalmittelung: Normwerte und Einflussfaktoren auf die fetale Akzelerations- und Dezelerationskapazität

2. Normwerte Herzzeitintervalle

  • AGENDA-PR Studie: Autonomic nervous system of fetuses with maternal GEstatioNal DiAbetes during PRegnancy: Doktorandin M. Sewald, Dr. A. Wacker-Gußmann (DHZ), Prof. Dr. R. Oberhoffer (DHZ München, Präventive Pädiatrie), Dr. S.M. Lobmaier (Frauenklinik rechts der Isar): Einfluss von Gestationsdiabetes auf Herzzeitintervalle und auf das fetale autonome Nervensystem
  • OLAF Studie: effects of Opioids during LAbour on Fetal autonomic nervous system:  Doktorand T. Hammerl, Dr. SM Lobmaier, Dr. JU Ortiz (beide Frauenklinik rechts der Isar): Einfluss von Opioiden (PDA/PCA/Analgesie) unter der Geburt auf das fetale autonome Nervensystem
  • KIND Studie: KorrelatIon und progNostischer Wert von Dezelerationsflächen und der Dezelerationskapazität für das fetale Outcome-. Kooperationsprojekt TRIUM (Hr. Daumer, C. Weber, M. Saalfeld)/TUM (Dr. J. Weyrich, Dr. Grundmann, Dr. SM Lobmaier)
  • Analyse der Expression von Kandidatengenen in Plazenta und des peripheren Zytokinprofils sowie des Vitamin D Status und des Mikrobioms zum Zeitpunkt der Geburt: Doktorandin J. Harder/Ester Ludwig, Dr. SM Lobmaier, PD Dr. C. Prazeres da Costa
  • TRUFFLE study group: Phase-rectified signal averaging (PRSA) method in early IUGR and correlation with neonatal and longterm outcome (PRsA on Truffle data: PRAT study)


Zusammenstellung der Veröffentlichungen der Forschergruppe:


Originalpublikationen

JIF

2023


Stampalija T, Wolf H, Mylrea-Foley B, Marlow N, Stephens KJ, Shaw CJ, Lees CC; TRUFFLE-2 Feasibility Study authors. Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction. Am J Obstet Gynecol. 2023 Jan;228(1):71.e1-71.e10. doi: 10.1016/j.ajog.2022.06.023. Epub 2022 Jun 23.

9.5

Familiari A, Napolitano R, Visser GHA, Lees C, Wolf H, Prefumo F; TRUFFLE-2 feasibility study investigators. Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort. Ultrasound Obstet Gynecol. 2023 Feb;61(2):191-197. doi: 10.1002/uog.26127.

8.1

2022


Bruin CM, Lobmaier SM, Ganzevoort W, Müller A, Wolf H. Comparison of phase rectified signal averaging and short term variation in predicting perinatal outcome in early onset fetal growth restriction. J Perinat Med. 2022 Nov 29. doi: 10.1515/jpm-2022-0409. Online ahead of print.

2.3

Sharma R, Frasch MG, Zelgert C, Zimmermann P, Fabre B, Wilson R, Waldenberger M, MacDonald JW, Bammler TK, Lobmaier SM, Antonelli MC. Maternal-fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study. Clin Epigenetics. 2022 Jul 14;14(1):87. doi: 10.1186/s13148-022-01310-x.

7.2

Karge A, Lobmaier SM, Haller B, Kuschel B, Ortiz JU. Value of Cerebroplacental Ratio and Uterine Artery Doppler as Predictors of Adverse Perinatal Outcome in Very Small for Gestational Age at Term Fetuses. J Clin Med. 2022 Jul 3;11(13):3852. doi: 10.3390/jcm11133852

5.1

Karge A, Desing L, Haller B, Ortiz JU, Lobmaier SM, Kuschel B, Graupner O. Performance of sFlt-1/PIGF Ratio for the Prediction of Perinatal Outcome in Obese Pre-Eclamptic Women. J Clin Med. 2022 May 27;11(11):3023. doi: 10.3390/jcm11113023.

5.1

Zimmermann P, Antonelli MC, Sharma R, Müller A, Zelgert C, Fabre B, Wenzel N, Wu HT, Frasch MG, Lobmaier SM. Prenatal stress perturbs fetal iron homeostasis in a sex specific manner. Sci Rep. 2022 Jun 4;12(1):9341. doi: 10.1038/s41598-022-13633-z.

5.5

Ortiz JU, Eixarch E, Micheletti T, Lobmaier SM, Bennasar M, Martinez JM, Gratacós E. Impact of Preoperative Cervical Length on Pregnancy Outcome in Twin-Twin Transfusion Syndrome. Z Geburtshilfe Neonatol. 2022 Aug;226(4):245-250. doi: 10.1055/a-1812-5608. Epub 2022 May 11.

0.7

Mylrea-Foley B, Thornton JG, Mullins E, Marlow N, Hecher K, Ammari C, Arabin B, Berger A, Bergman E, Bhide A, Bilardo C, Binder J, Breeze A, Brodszki J, Calda P, Cannings-John R, Černý A, Cesari E, Cetin I, Dall'Asta A, Diemert A, Ebbing C, Eggebø T, Fantasia I, Ferrazzi E, Frusca T, Ghi T, Goodier J, Greimel P, Gyselaers W, Hassan W, Von Kaisenberg C, Kholin A, Klaritsch P, Krofta L, Lindgren P, Lobmaier S, Marsal K, Maruotti GM, Mecacci F, Myklestad K, Napolitano R, Ostermayer E, Papageorghiou A, Potter C, Prefumo F, Raio L, Richter J, Sande RK, Schlembach D, Schleußner E, Stampalija T, Thilaganathan B, Townson J, Valensise H, Visser GH, Wee L, Wolf H, Lees CC; TRUFFLE 2 Collaborators List. Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol. BMJ Open. 2022 Apr 15;12(4):e055543. doi: 10.1136/bmjopen-2021-055543.

3.6

Zöllkau J, Ankert J, Pletz MW, Mishra S, Seliger G, Lobmaier SM, Prazeres Da Costa CU, Seidel V, Weizsäcker KV, Jablonka A, Dopfer C, Baier M, Horvatits T, Reiter-Owona I, Groten T, Schleenvoigt BT. Hepatitis E, Schistosomiasis and Echinococcosis-Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction. Pathogens. 2022 Jan 3;11(1):58. doi: 10.3390/pathogens11010058.

4.6

Wacker-Gussmann A, Engelhard J, Oberhoffer-Fritz R, Schopen J, Ewert P, Ortiz JU, Haller B, Graupner O, Lobmaier SM. Cardiovascular outcome of former late-onset small-for-gestational-age children at 1 year of age: CURIOSA study. Arch Gynecol Obstet. 2022 Nov;306(5):1455-1461. doi: 10.1007/s00404-022-06404-8.

2.8

2021


Wacker-Gussmann A, Schopen J, Engelhard J, Sitzberger C, Lienert N, Ewert P, Müller A, Schmidt G, Oberhoffer-Fritz R, Lobmaier SM. The Impact of Gestational Diabetes in Pregnancy on the Cardiovascular System of Children at One Year of Age. J Clin Med. 2021 Dec 13;10(24):5839. doi: 10.3390/jcm10245839

4.6

Sarkar P, Lobmaier S, Fabre B, González D, Mueller A, Frasch MG, Antonelli MC, Etemad A. Detection of maternal and fetal stress from the electrocardiogram with self-supervised representation learning. Sci Rep. 2021 Dec 17;11(1):24146. doi: 10.1038/s41598-021-03376-8.

5.1

Mylrea-Foley B, Wolf H, Stampalija T, Lees C; Truffle-2 Group; Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction. Ultraschall Med. 2023 Feb;44(1):56-67. doi: 10.1055/a-1511-8293. Epub 2021 Nov 12

6.5

Habib M, Adegnika AA, Honkpehedji J, Klug SJ, Lobmaier S, Vogg K, Bustinduy AL, Ullrich A, Reinhard-Rupp J, Esen M, Prazeres da Costa C. The challenges for women's health in sub-Saharan Africa: Lessons learned from an integrative multistakeholder workshop in Gabon. J Glob Health. 2021 Sep 4;11:02002. doi: 10.7189/jogh.11.02002.

5.2

Ortiz JU, Graupner O, Karge A, Flechsenhar S, Haller B, Ostermayer E, Abel K, Kuschel B, Lobmaier SM. Does gestational age at term play a role in the association between cerebroplacental ratio and operative delivery for intrapartum fetal compromise? Acta Obstet Gynecol Scand. 2021 Oct;100(10):1910-1916. doi: 10.1111/aogs.14222. Epub 2021 Jul 17

3.6

Ortiz JU, Torres X, Bennasar M, Eixarch E, Gómez O, Crovetto F, Lobmaier SM, Martinez JM, Gratacós E, Crispi F. Left myocardial performance index in monochorionic diamniotic twin pairs complicated by selective fetal growth restriction with abnormal umbilical artery Doppler. Prenat Diagn. 2021 Nov;41(12):1504-1509. doi: 10.1002/pd.6037. Epub 2021 Sep 2

3.1

Graupner O, Ried C, Wildner N, Ortiz JU, Kuschel B, Haller B, Oberhoffer R, Wacker-Gußmann A, Lobmaier SM. Myocardial deformation analysis in late-onset small-for-gestational-age and growth-restricted fetuses using two-dimensional speckle tracking echocardiography: a prospective cohort study. J Perinat Med. 2021 Sep 17;50(3):305-312.

1.6

Ortiz JU, Graupner O, Flechsenhar S, Karge A, Ostermayer E, Abel K,  Kuschel B, Lobmaier SM. Prognostic value of cerebroplacental ratio in appropriate-for-gestational-age fetuses before induction of labor in late-term pregnancies. Ultraschall Med. 2023 Feb;44(1):50-55. doi: 10.1055/a-1399-8915. Epub 2021 May 31.

6.5

Lobmaier SM, Graupner O, Ortiz JU, Haller B, Ried C, Wildner N, Abel K, Kuschel B, Rieger-Fackeldey E, Oberhoffer-Fritz R, Wacker-Gußmann A. „Perinatal outcome and its prediction using longitudinal feto-maternal Doppler follow-up in late onset small for gestational age fetuses- a prospective cohort study. Ultraschall Med. 2023 Apr;44(2):e108-e117. doi: 10.1055/a-1493-2367. Epub 2021 Jun 8.

6.5

Karge A, Seiler A, Flechsenhar S, Haller B, Ortiz JU, Lobmaier SM, Axt-Fliedner R, Enzensberger C, Abel K, Kuschel B, Graupner O. Prediction of adverse perinatal outcome and the mean time until delivery in twin pregnancies with suspected pre-eclampsia using sFlt-1/PIGF ratio. Pregnancy Hypertens 2021 Jun;24:37-43. doi: 10.1016/j.preghy.2021.02.003

2.1

Wolf H, Stampalija T, Lees CC; TRUFFLE study group. Fetal cerebral blood flow redistribution: an analysis of Doppler reference charts and the association of different thresholds with adverse perinatal outcome. Ultrasound Obstet Gynecol. 2021 Nov;58(5):705-715. doi: 10.1002/uog.23615

5.6

Ankert J, Groten T, Pletz MW, Mishra S, Seliger G, Lobmaier SM, da Costa CP, Seidel V, von Weizsäcker K, Jablonka A, Dopfer C, Schleenvoigt BT. Fetal growth restriction in a cohort of migrants in Germany. BMC Pregnancy Childbirth. 2021 Feb 17;21(1):145. doi: 10.1186/s12884-021-03620-z.

3.1

2020


Pecks U, Kuschel B, Mense L, Oppelt P, Rüdiger M; CRONOS Network. Pregnancy and SARS-CoV-2 Infection in Germany-the CRONOS Registry. Dtsch Arztebl Int. 2020 Dec 4;117(49):841-842. doi: 10.3238/arztebl.2020.0841.

5.1

Butenschoen VM, Hitscherich H, Eicker SO, Lobmaier SM, Rösler J, Bretschneider M, Kirschke JS, Vajkoczy P, Kögl N, Constanthin P, Thome C, Tessitore E, Meyer B, Wostrack M. Spine surgery in pregnant women: a multicenter case series and proposition of treatment algorithm. Eur Spine J. 2021 Apr;30(4):809-817

2.6

Hoyer D, Schmidt A, Pytlik A, Viehöfer L, Goncalves H, Amorim-Costa C, Bernardes J, Ayres-de-Campos D, Lobmaier SM, Schneider U. Can fetal heart rate variability obtained from cardiotocography provide the same diagnostic value like from electrophysiological interbeat intervals? Physiol Meas. 2021 Feb 11;42(1):015006. doi: 10.1088/1361-6579/abc791.

2.3

Karge A, Beckert L, Moog P, Haller B, Ortiz JU, Lobmaier SM, Abel K, Flechsenhar S, Kuschel B, Graupner O. Role of sFlt-1/PIGF ratio and uterine Doppler in pregnancies with chronic kidney disease suspected with Pre-eclampsia or HELLP syndrome. Pregnancy Hypertens. 2020 Oct;22:160-166. doi: 10.1016/j.preghy.2020.09.007. Epub 2020 Sep 17.

2.1

Sitzberger C, Oberhoffer-Fritz R, Meyle K, Wagner M, Lienert N, Graupner O, Ensenauer R, Lobmaier SM,  Wacker-Gußmann A. Gestational diabetes: physical activity before pregnancy and its influence on the cardiovascular system. Frontiers in Pediatrics. 2020 Aug 14;8:465. doi: 10.3389/fped.2020.00465.

2.3

Stampalija T, Thornton J, Marlow N, Napolitano R, Bhide A, Pickles T, Bilardo CM, Gordijn SJ, Gyselaers W, Valensise H, Hecher K, Sande RK, Lindgren P, Bergman E, Arabin B, Breeze AC, Wee L, Ganzevoort W, Richter J, Berger A, Brodszki J, Derks J, Mecacci F, Maruotti GM, Myklestad K, Lobmaier SM, Prefumo F, Klaritsch P, Calda P, Ebbing C, Frusca T, Raio L, Visser GHA, Krofta L, Cetin I, Ferrazzi E, Cesari E, Wolf H, Lees CC; TRUFFLE-2 Group. Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study. Ultrasound Obstet Gynecol. 2020 Aug;56(2):173-181. doi: 10.1002/uog.22125.

5.6

Weyrich J, Ortiz JU, Müller A, Schmidt G, Brambs CE, Graupner O, Kuschel B, Lobmaier SM. Intrapartum PRSA: a new method to predict fetal acidosis?-a case-control study. Arch Gynecol Obstet. 2020 Jan;301(1):137-142. doi: 10.1007/s00404-019-05419-y.

2.2

Lobmaier SM, Müller A, Zelgert C, Shen C, Su PC, Schmidt G, Haller B, Berg G, Fabre B, Weyrich J, Wu HT, Frasch MG, Antonelli MC. Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG. Arch Gynecol Obstet. 2020 Feb;301(2):405-414. doi: 10.1007/s00404-019-05390-8.

2.2

Graupner O, Karge A, Flechsenhar S, Seiler A, Haller B, Ortiz JU, Lobmaier SM, Axt-Fliedner R, Enzensberger C, Abel K, Kuschel B. Role of sFlt-1/PlGF ratio and feto-maternal Doppler for the prediction of adverse perinatal outcome in late-onset pre-eclampsia. Arch Gynecol Obstet. 2020 Feb;301(2):375-385. doi: 10.1007/s00404-019-05365-9.

2.2

2019


Ludwig E, Harder J, Lacorcia M, Honkpehedji YJ, Nouatin OP, van Dam GJ, Corstjens PLAM, Sartono E, Esen M, Lobmaier SM, Adegnika AA, Prazeres da Costa C. Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country. Sci Rep. 2019 Oct 31;9(1):15776.

4.0

Fratelli N, Prefumo F, Wolf H, Hecher K, Visser GHA, Giussani D, Derks JB, Shaw CJ, Frusca T, Ghi T, Ferrazzi E, Lees CC; TRUFFLE Group; TRUFFLE Group authors; Effects of Antenatal Betamethasone on Fetal Doppler Indices and Short Term Fetal Heart Rate Variation in Early Growth Restricted Fetuses. Ultraschall Med. 2019 Feb;42(1):56-64

4.6

Graupner O, Helfrich F, Ostermayer E, Lobmaier SM, Ortiz JU, Ewert P, Wacker-Gussmann A, Haller B, AxtFliedner R, Enzensberger C, Abel K, Karge A, Oberhoffer R, Kuschel B. Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: Late trimester biometry, cerebroplacental hemodynamics and perinatal outcome. Arch Gynecol Obstet. 2019 Sep;300(3):601-613. doi: 10.1007/s00404-019-05198-6.

2.2

Ganzevoort W, Thornton JG, Marlow N, Thilaganathan B, Arabin B, Prefumo F, Lees C, Wolf H; GRIT study group; TRUFFLE-study group. Comparative analysis of the 2-year outcomes in the GRIT and TRUFFLE trials. Ultrasound Obstet Gynecol. 2020 Jan;55(1):68-74. doi: 10.1002/uog.20354.

5.6

Hoyer D, Schmidt A, Gustafson KM, Lobmaier SM, Lakhno IV, Van Leeuwen P, Cysarz D, Preissl H, Schneider U. Heart rate variability categories of fluctuation amplitude and complexity - diagnostic markers of fetal development and its disturbances. Physiol Meas. 2019 Jul 3;40(6):064002. doi: 10.1088/1361-6579/ab205f.

2.0

Ortiz JU, Hammerl T, Wasmaier M, Wienerroither V, Hamann M, Kuschel B, Lobmaier SM. Influence of different methods of intrapartum analgesia on the progress of labour and on perinatal outcome. Geburtshilfe und Frauenheilkunde 2019 Apr;79(4):389-395. 

1.3

Graupner O, Ortiz JU, Plankl C, Haller B, Wacker-Gussmann A, Oberhoffer R, Kuschel B, Lees CC, Lobmaier SM. Performance of computerized cardiotocography based short-term variation in late-onset fetal growth restricted fetuses and reference ranges for the late third trimester. Arch Gynecol Obstet 2019 Apr;79(4):389-395.

 2.2

2018


Graupner O, Lobmaier SM, Ortiz JU, Karge A, Kuschel B. sFlt-1/PlGF ratio for the prediction of the time of delivery. Arch Gynecol Obstet. 2018 Sep;298(3):567-577.

 2.2


Vogel T, Wrobel RM, Graupner O, Lobmaier S, Feussner H, Kuschel B. Esophageal achalasia and pregnancy: own observations in 43 patients and a review of the literature. Arch Gynecol Obstet. 2018 Sep;298(3):511-519. doi: 10.1007/s00404-018-4819-0.

 2.2

Schiermeier S, Frisenda S, Reinhard J, Dagres T, Noé KG, Lobmaier S, Schneider KTM, Daumer M. Intrapartum Foetal Heart Rate Monitoring and Rate of Caesarean Section: A National Survey. Z Geburtshilfe Neonatol. 2018 Jun;222(3):117-122.

 0.3

Ortiz JU, Torres X, Eixarch E, Bennasar M, Cruz-Lemini M, Gómez O, Lobmaier SM, Martínez JM, Gratacós E, Crispi F. Differential Changes in Myocardial Performance Index and Its Time Intervals in Donors and Recipients of Twin-to-Twin Transfusion Syndrome before and after Laser Therapy. Fetal Diagn Ther. 2018;44(4):305-310.

2.0

Lobmaier SM, Ortiz JU, Sewald M, Müller A, Schmidt G, Haller B, Oberhoffer R, Schneider KTM, Giussani DA, Wacker-Gußmann A. Influence of gestational diabetes on the fetal autonomic nervous system: A study using phase-rectified signal averaging analysis. Ultrasound Obstet Gynecol. 2018 Sep;52(3):347-351.

5.7

Wacker-Gussmann A, Plankl C, Sewald M, Schneider KM, Oberhoffer R, Lobmaier SM. Fetal cardiac time intervals in healthy pregnancies - an observational study by fetal ECG (Monica Healthcare System). J Perinat Med. 2018 Aug; 46:587-592.

1.6

2017


Bilardo CM, Hecher K, Visser GHA, Papageorghiou AT, Marlow N, Thilaganathan B, Van Wassenaer-Leemhuis A, Todros T, Marsal K, Frusca T, Arabin B, Brezinka C, Derks JB, Diemert A, Duvekot JJ, Ferrazzi E, Ganzevoort W, Martinelli P, Ostermayer E, Schlembach D, Valensise H, Thornton J, Wolf H, Lees C; TRUFFLE Group. Severe fetal growth restriction at 26-32 weeks: key messages from the TRUFFLE study. Ultrasound Obstet Gynecol. 2017 Sep;50(3):285-290.

5.7

Weyrich J, Setter A, Müller A, Schmidt G, Brambs CE, Ortiz JU, Lobmaier SM. Longitudinal progression of fetal short-term variation and average acceleration and deceleration capacity after antenatal maternal betamethasone application. Eur J Obstet Gynecol Reprod Biol. 2017; 212:85-90.

1.8

Ganzevoort W, Mensing Van Charante N, Thilaganathan B, Prefumo F, Arabin B, Bilardo CM, Brezinka C, Derks JB, Diemert A, Duvekot JJ, Ferrazzi E, Frusca T, Hecher K, Marlow N, Martinelli P, Ostermayer E, Papageorghiou AT, Schlembach D, Schneider KTM, Todros T, Valcamonico A, Visser GHA, Van Wassenaer-Leemhuis A, Lees CC, Wolf H; TRUFFLE Group. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study. Ultrasound Obstet Gynecol. 2017 Jun;49(6):769-777.

5.6

Stampalija T, Arabin B, Wolf H, Bilardo CM, Lees C; TRUFFLE investigators. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction? Am J Obstet Gynecol. 2017 May;216(5):521.e1-521.e13.

5.7

Wolf H, Arabin B, Lees CC, Oepkes D, Prefumo F, Thilaganathan B, Todros T, Visser GHA, Bilardo CM, Derks JB, Diemert A, Duvekot JJ, Ferrazzi E, Frusca T, Hecher K, Marlow N, Martinelli P, Ostermayer E, Papageorghiou AT, Scheepers HCJ, Schlembach D, Schneider KTM, Valcamonico A, van Wassenaer-Leemhuis A, Ganzevoort W; TRUFFLE group. Longitudinal study of computerized cardiotocography in early fetal growth restriction. Ultrasound Obstet Gynecol. 2017 Jul;50(1):71-78.

5.7

Visser GHA, Bilardo CM, Derks JB, Ferrazzi E, Fratelli N, Frusca T, Ganzevoort W, Lees CC, Napolitano R, Todros T, Wolf H, Hecher K; TRUFFLE group investigators. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study. Ultrasound Obstet Gynecol. 2017 Sep;50(3):347-352.

 5.7

Ortiz JU, Masoller N, Lobmaier SM, Bennasar M, Crispi F, Gómez O, Gratacós E, Martinez JM. Rate and outcomes after laser surgery of right ventricle outflow tract obstruction in recipient twins with twin-twin transfusion syndrome, Fetal Diagn Ther. 2017;41:191-196

1.8

2016


Ortiz JU, Eixarch E, Peguero A, Lobmaier SM, Bennasar M, Martinez JM, Gratacós E. Chorioamniotic membrane separation after fetoscopy in monochorionic twin pregnancies: incidence and impact on perinatal outcome. Ultrasound Obstet Gynecol. 2016;47:345-9

4.2

Lobmaier SM, Mensing van Charante N, Ganzevoort W, Giussani DA, Shaw CJ, Müller A, Ortiz JU, Ostermayer E, Haller B, Prefumo F, Frusca T, Hecher K, Thilaganathan B, Papageorghiou AT, Bhide A, Martinelli P, Duvekot JJ, van Eyck J, Visser GHA, Schmidt G, Wolf H, Ferrazzi E, Lees C, Schneider KTM and TRUFFLE study investigators. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial, Am J Obstet Gynecol. 2016 Nov;215(5):630.e1-630.e7

5.7


Reviews und Fallberichte

JIF

2021


4. Antonelli MC, Frasch MG, Rumi M, Sharma R, Zimmermann P, Molinet MS, Lobmaier SM. Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress. Curr Neuropharmacol. 2022;20(1):94-106. doi: 10.2174/1570159X19666210125150955.

8.3

2018


3. Frasch MG, Lobmaier SM, Stampalija T, Desplats P, Pallares ME, Pastor V, Brocco V, Wu HT, Schulkin J, Herry C, Seely A, Metz G, Louzoun Y, Antonelli MC. Non-invasive biomarkers of fetal brain development reflecting prenatal stress: an integrative multi-scale multi-species perspective on data collection and analysis. Neurosci Biobehav Rev. 2020 Oct;117:165-183. doi: 10.1016/j.neubiorev.2018.05.026

9.0

2. Wacker-Gussmann A, Esser T, Lobmaier SM, Vogt MO, Ostermayer E, Oberhoffer R. Prenatally diagnosed isolated coronary arterial fistula leading to severe complications at birth. Case Rep Cardiol. 2018 Mar 26;2018:2509502. doi: 10.1155/2018/2509502



Prof. Dr. med. Silvia M. Lobmaier

Fachärztin für Gynäkologie und Geburtshilfe, ltd. Oberärztin
DEGUM II, Schwerpunktbezeichnung spezielle Geburtshilfe und Perinatalmedizin


Frauenklinik und Poliklinik
Klinikum rechts der Isar
der Technischen Universität München

Ismaningerstr. 22
81675 München


Tel. +49 89 4140 5417


silvia.lobmaier@tum.de(link sends e-mail)