Gynecologic Tumor
Immunology

PD Dr. Holger Bronger

The immune system is an inherently effective weapon in the fight against cancer. However, tumors develop various ways to help them effectively evade such immune intervention. The clarification of these so-called immune escape mechanisms has led to the development of completely novel immunotherapies over the last two decades. However, a basic prerequisite for the success of all these therapies is that the immune effector cells find their way into the tumor in the first place. Our research group is investigating how the infiltration of immune cells into solid tumors is controlled and how this can be used to improve immunotherapies, particularly in gynecological cancers. The systems we study play a central role in almost all drug classes currently used in gynecological oncology, especially PARP and immune checkpoint inhibitors.

CXCL9 inhibits tumor growth and drives anti-PD-L1 therapy in ovarian cancer. Seitz S, Dreyer TF, Stange C, Steiger K, Bräuer R, Scheutz L, Multhoff G, Weichert W, Kiechle M, Magdolen V, Bronger H. British Journal of Cancer 2022; 126(10): 1470-80.

The chemokine CX3CL1 improves trastuzumab efficacy in HER2 low-expressing cancer in vitro and in vivo. Dreyer T, Kuhn S, Stange C, Heithorst N, Schilling D, Jelsma J, Sievert W, Seitz S, Stangl S, Hapfelmeier A, Noske A, Wege AK, Weichert W, Ruland J, Schmitt M, Dorn J, Kiechle M, Reuning U, Magdolen V, Multhoff G, Bronger H. Cancer Immunology Research 2021; 9(7): 765-78.(link is external)

Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors. Bronger H. , Magdolen V., Goettig P., Dreyer T. Cancer and Metastasis Reviews 2019; 38(3): 417-30.(link is external)

CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients. Windmüller C., Zech D., Avril S., Boxberg M., Dawidek T., Schmalfeldt B., Schmitt M., Kiechle M., Bronger H. Oncogenesis 2017; 6(5):e331.(link is external)

CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibitors in advanced serous ovarian cancer. Bronger H., Singer J., Windmüller C., Reuning U., Zech D., Delbridge C., Dorn J., Kiechle M., Schmalfeldt B., Schmitt M., Avril S. British Journal of Cancer 2016; 115(5): 553-63.(link is external)

Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping. Wulfkuhle J.D., Berg D., Wolff C., Langer R., Tran K., Illi J., Espina V., Pierobon M., Deng J., DeMichele A., Walch A., Bronger H., Becker I., Waldhör C., Schuster T., Höfler H., Esserman L., Liotta L.A., Becker K.F., Petricoin III E.F. Clinical Cancer Research 2012; 18(23): 6426-35.(link is external)

Modulation of CXCR3 Ligand Secretion by Prostaglandin E2 and Cyclooxygenase Inhibitors in Human Breast Cancer. Bronger H., Kraeft S., Schwarz-Boeger U., Cerny C., Stöckel A., Avril S., Kiechle M., Schmitt M. Breast Cancer Research 2012; 14(1): R30.(link is external)

ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier. Bronger H., König J., Kopplow K., Steiner H.H., Ahmadi R., Herold-Mende C., Keppler D., Nies A.T. Cancer Research 2005; 65: 11419-28.(link is external)