Tumor-associated Proteolysis

Prof. Dr. Viktor Magdolen

Extracellular proteolytic processes play an important role for the regulation of cell-cell and cell-matrix contacts. Under physiological conditions, many different proteases (mostly serine, cysteine and matrix metallo proteases) form a complex extracellular network, which is counter-balanced by a series of natural inhibitors. Under pathophysiological conditions, e.g. in solid tumors, often a dysregulation of certain proteases or inhibitors is observed resulting in an increased tumor growth, invasion and metastasis. In our group, we mainly focus on the analysis of the tumor biological role of extracellular serine proteases and their associated proteins as well the clinical relevance of these factors concerning prognosis and response to treatment.

Prof. Dr. rer. nat. Viktor Magdolen
Clinical Research Unit
Department of Gynecology and Obstetrics
Technical University of Munich
Ismaninger Str. 22
81675 München

Tel.: 089-4140-2493
Fax: 089-4140-7410
Mail: viktor magdolen@tum.de(link sends e-mail)